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Create custom cell lines in 80% less time



Presenter: Matt Handel


Monday, April 8, 2019

Embassy Suites, Chesterbrook, Pennsylvania (directions)




ExpressCells uses genetic editing to create custom cell lines for biological research. Its approach uses CRISPR, plus its patent-pending plasmid system to create pure cell lines in 80% less time than current technology. Its living cells replicate diseases or have proteins glow in multiple colors, speeding drug development. Via multi-channel marketing (e-commerce, online promotion, publications, distributors), ExpressCells plans to generate revenue in 2019.


Customer Problem:  Biological researchers need to identify how new drugs and biologics work within cells. To do so, they test these products in cell lines -- humancells propagated in lab culture. These cell lines are often genetically altered in order to study a specific protein, but current processes take 4-6 months, the modifications are limited, and altered cells are often killed in order to study the protein of interest.


Product/Services:  ExpressCells combines CRISPR with a proprietary plasmid system that uses DNA in a modular form for quick insertion into living cells. The first vectors are reporters: fluorescent genes that illuminate target proteins and allow researchers to visually observe cellular activity in live cells. ExpressCells technology can insert other types of genes. ExpressCells plans to produce custom cell lines in as few as 30 days. ExpressCells can insert multiplegenes into one cell line.


Target Market:  The global market for cell lines, both off-the-shelf and custom, was $2 billion in 2015; over $500M in the U.S. The purchasers are lab scientists, often working in drug development where delays of 4-5 months can erase millions of dollars of value. Many customers are in large pharma companies and CRO's that can provide ongoing work or become partners. Others are small and start-up pharma and biotech that can be reached online and via distributors.


Executive Summary

Management:  Matt Handel, CEO: 25+ years experience. Product dev't, business dev't and commercial at Merck and Shire. Experienced fund-raiser, operations lead. Princeton/MIT.


Oscar Perez Leal, MD, Founder: 15 years at TempleSchool of Pharmacy researching biochemistry and molecular biology. Inventor on multiple patents. Medical and business degrees. 


David Becker, MD, Commercial Advisor: Former President, Exeter Group. Sold into pharma for 20+ years. Yale/NYU/MIT.



3 Major Issues


  1. When discussing revenues/valuation, how do we explain a forecast based on existing products (no technical risk) and on products in development (technical risk)?
  2. Which commercial tactics should we use to access customers?
  3. Since we do not yet have customers, how can we demonstrate customer interest and acceptance of our products?





6:30 - Cocktails & Dinner (Cash bar and special 2-entree buffet menu)

7:45 - Matt Handel, CEO of ExpressCells, will deliver "Elevator" Pitch to the Group

8:00 - A Panel will address three major issues crucial to helping the Company reach the next level.

9:00 - Open discussion: members and guests




Available Media

Please note: All information obtained here is the property of those presenting and should not be copied or duplicated without written consent.



None available at this time


None available at this time


None available at this time


ExpressCells Webcast - 04/08/2019


To review the webcast recording, drag the playhead to any part of the presentation. 

00:00:00  Presentation by Matthew Handel      
00:25:00  Panel Introductions (three panelists)
00:28:00  Maureen Mulvihill comments            
00:41:50  Susan Maley comments                    
00:54:00  Mike Daley comments                       
00:59:45  Audience discussion begins              

If you have problems, contact Tom Thompson,


The webcast recording of the PCCI meeting is posted on the PCCI website a few days after the event.

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Contact: Peter van der Kam, | (610) 296-8086




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