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OptoVibronex, LLC

Non-invasive technique for biopsies of skin carcinomas


Presenter: Frederick Silver


Monday, March 11, 2019

Embassy Suites, Chesterbrook, Pennsylvania (directions)




Vibrational optical coherence tomography (VOCT) is a new technology that combines the imaging power of optical coherence tomography with what amounts to ultrasound to characterize the physical properties of tissues. This technology has been developed to perform “virtual” biopsies and biomechanical measurements on normal and malignant tissues non-invasively and non-destructively.  In addition, results are obtained within 15 minutes and at less cost.


Cutaneous wound healing and the development of malignant skin lesions can be associated with changes in tissue stiffness. VOCT produces images of groups of cells as well as biomechanical information in three dimensions that can distinguish normal from pathological tissue. In addition, the biomechanical properties of the tissue margins can be characterized.


The images and the biomechanical data from measurements made on different skin lesions and carcinomas together can help plan surgical interventions and monitor the healing process of skin lesions. VOCT produces images of groups of cells as well as measurement of the tissue resonant frequency in three dimensions which assists in distinguishing normal from pathological tissue.


OptoVibronex has imaged and studied several types of skin lesions using VOCT to evaluate the morphology, stiffness, depth and margins of these structures. While cellular components present in skin and carcinomas have resonant frequencies in the range of 30 to 60 Hz, normal collagen has a resonant frequency in the range greater than 90 Hz. In comparison, fibrotic collagen is shown to have resonant frequencies above 150 Hz as does collagen from skin lesions.


The ratio of the resonant frequency squared to the tissue thickness obtained from VOCT can be used to grade the type of tissue response seen. Further studies are underway to establish the relationship between tissue stiffness and lesion morphology for cellular and fibrotic lesions based on the characteristic ratios of resonant frequency and tissue thickness.



3 Major Issues


  1. Advice on sources for non-dilutive financing options - including, but not limited to, strategies on how to secure NIH/NSF funding.
  2. Advice on how to market to different medical markets (i.e., different types of physicians' practices, urgent care facilities, hospitals)
  3. How to identify and approach potential sub-licensing partners. Who should we be targeting?





6:30 - Cocktails & Dinner (Cash bar and special 2-entree buffet menu)

7:45 - Frederick Silver, President of OptoVibronex, will deliver "Elevator" Pitch to the Group

8:00 - A Panel will address three major issues crucial to helping the Company reach the next level.

9:00 - Open discussion: members and guests




Available Media

Please note: All information obtained here is the property of those presenting and should not be copied or duplicated without written consent.



None available at this time


None available at this time


None available at this time


OptoVibronex Webcast


The webcast recording of the PCCI meeting is posted on the PCCI website a few days after the event.

Contact Info:



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New Jersey Institute of Technology
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